On NPR, Jeanne Martinet author of The Art of Mingling: Proven Techniques for Mastering Any Room walks the host through a mock party to show how to talk with people at parties even if you don't know them or anything about them. Check out the audio for the full story.
Like most things in life, this is mostly common sense but it always helps for someone to put that sense into practice and show how it is done. I've been at parties where people have used the "honest approach" and it definitely works–and if it doesn't then get out as soon as you can.
Link via: The Old New Thing